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Overview of most popular Injectable Fillers
by Celluline, Last update: Jan 30, 2016


Description: BOTOX® Cosmetic is made of the purified form of a toxin, which blocks the nerve impulses to the facial muscles that cause wrinkles.

How it's done:

Physician will target the muscles that contract to cause your wrinkles. Each muscle will receive about three injections, and the entire treatment lasts 10 to 30 minutes.

Cosmetic condition & treatment area: Frown lines, crow’s feet, thick bands in the neck, and all facial wrinkles
Recovery: No downtime.
Complications: It’s common to experience some stinging at the injection site, while some patients experience bruises, small red marks, or swelling at the site.
Lasting: Last up to four months, as the effects of your BOTOX® treatment wear off, your wrinkles will return.
Cost: From 200$ or usually costs around $250 per location.


Description: New, April 2011. Injections of this diluted toxin block the release of a chemical called acetylcholine (also found in the nerves in the underarm that cause sweating), paralyzing the muscle and erasing wrinkles.

How it's done: The doctor applies Dysport to the skin using a thin needle. The slight burning sensation this causes disappears immediately after the substance has been applied. The skin is desensitized with cream at sensitive places, like the lips.
Cosmetic condition & treatment area:

Forehead wrinkles and frown lines.

Recovery: One to two days.
Complications: Nose and throat irritation, headache, injection site pain, injection site skin reaction, upper respiratory tract infection, eyelid swelling, eyelid drooping, sinus inflammation, and nausea. These are all the same side effects associated with Botox.

3 to 6 months.

Cost: $300 pe


Description: Since July 2011 XEOMIN® is now available in Canada. Botulinum neurotoxin type A is considered by many to be the treatment of choice for focal spasticity9,10,11 and dystonia7.

How it's done: The doctor applies XEOMIN® to the skin using a thin needle. The slight burning sensation this causes disappears immediately after the substance has been applied.
Cosmetic condition & treatment area:

Neck spasms/involuntary blinking

Recovery: One to two days.
Complications: Injection site bruising or bleeding.

3 to 6 months.

Cost: $500 per syringe


Description: Instead of being produced from animal sources, however, they are both derived from bacteria that produce hyaluronic acid. The Restylane®  gel is composed of hyaluronic acid, a natural substance already present in the human body.

How it's done: The doctor applies RESTYLANE® to the skin using a thin needle. The slight burning sensation this causes disappears immediately after the substance has been applied. The skin is desensitized with cream at sensitive places, like the lips.
Cosmetic condition & treatment area:

Reduction of superficial wrinkles,  improvement of the contours of the lips and the vertical lip furrows, fuller lips, reduction of turned-down corners of the mouth, reduction of scars.

Recovery: One to two days.
Complications: Skin may be swollen directly after the treatment.

4 to 6 months.

Cost: $500 per syringe


Description: Perlane is in the same family as Restylane, with a larger particle size, approved by the FDA in May of 2011 for soft tissue augmentation of moderate to severe facial folds and wrinkles. Perlane is non-animal hyaluronic acid

How it's done: Because of its larger hyaluronic acid particle size, Perlane is injected into deeper folds than Restylane.
Cosmetic condition & treatment area: It is most commonly used in the nasolabial folds, marionette lines, and for augmentation of the cheeks.Since is less susceptible to breakdown in the body, Perlane is used for deeper wrinkles.
Recovery: few days
Complications: Skin may be swollen directly after the treatment., do not pose an allergy risk and are thought to be broken down at a slower rate than the collagen products.
Lasting: 3 to 6 months .
Cost: for lips: $300 to $700  per syringe


Description: Juvederm is largely comprised of hyaluronic acid, a substance normally found in the skin, muscles, and tendons of mammals. Approved in 2011 by the U.S. Food and Drug Administration (FDA).

How it's done: Hyaluronic acid can absorb up to 1,000 times its own weight in water, thereby adding new volume under the surface of sagging skin.
Cosmetic condition & treatment area: Correct moderate to deep folds, remove nasolabial folds, or “smile lines”. It is also used as a lip augmentation agent, to plump up lips, and to fill in hollow places and scars on the face.
Recovery: No recovery needed. The exception is the lips, where the swelling may be noticeable for up to one week.
Complications: Expected side effects include temporary redness, pain and tenderness during injections and swelling and bruising at the injection sites. The more serious side effects include immune system reactions that result in facial lumps and bumps known as granulomas, bothersome reactions that are very difficult for physicians to treat. Juvéderm should not be used in patients with severe allergies, particularly those who have allergies to bacterial proteins or patients with a history of anaphylaxis, which is a potentially life threatening hypersensitivity to some drugs and proteins.
Lasting: Up to 1 year.
Cost: Around $600 per syringe


Description: The newest collage-based filler, was cleared by the FDA 2011.

How it's done: It doesn't require a skin test like the old , cow based collagen filler.
Cosmetic condition & treatment area: Approved to treat  mild to  moderate nasolabial folds and marionette lines.
Recovery: Low risk of swelling, short or no downtime.
Complications: Evolence should not be injected around the eyes or into the lips because it can cause lumps and bumps in those areas. Evolence is not transparent like hyaluronic acid, so not recommended for those with tin skin
Lasting: Up to 6 months.
Cost: Evolence costs about $500 or more per syringe.

Artecoll (ArteFill)

Description: ArteFill is polymethylmethacrylate (PMMA) coupled with a purified bovine collagen gel carrier. The PMMA beads form a support matrix for your own collagen, which gradually replaces the bovine collagen carrier gel. ArteFill also includes lidocaine. Approved by the U.S. FDA in December, 2011.

How it's done: A collagen skin test must be performed one month prior to treatment. Patients with a positive skin test will not be treated with ArteFill. Treatment involves multiple injections to the site with a very thin needle. Anesthesia involves nerve blocks, topical numbing cream, or both.
Cosmetic condition & treatment area: Nasolabial folds that form around the mouth and for acne scars.
Recovery: Few days.
Complications: Large lumps under the skin known as granulomas might be developed after Artecoll injections. The lumps are a reaction to the injections and can be difficult for doctors to treat.
Lasting: Few years, some patients may require a second treatment. Follow up treatment is usually performed 3 to 6 months after initial injections.
Cost: Price per syringe is  around $1400.

Dermalive and Dermadeep

Description: Dermalive and Dermadeep are made of acrylic hydrogel and hyaluronic acid,  a non-animal origin, which reduce the risks of allergy. Dermalive and Dermadeep are not recommended for filling superficial wrinkles or for patients with thin skin. Dermalive and Dermadeep are complimentary products.

Scar Correction

How it's done: Dermalive and Dermadeep fillers can be used without a skin test, and they do not contain any preservatives or anesthetics.
Cosmetic condition & treatment area: Deep facial wrinkles, nasolabial folds, lips and facial contours (chin, cheeks)
Recovery: 1-2 days
Complications: A redness, swelling and pain, may develop after the injection, usually disappearing over time (up to 1-2 days). Occasionally, a localized inflammatory reaction or granulome may occur several months after the injection.
Lasting: Long lasting, few years
Cost: A typical Dermalive® or Dermadeep® treatment costs about $900 to $1000. The number of treatments needed depends on the patient’s individual case.


Description: A reliable filling agent for acne scars. Fibrel has been an effective method of elevating scars using 3 agents; porcine gelatin, amino caproic acid, and 1% lidocaine. Fiber is animal derived injectable collagens.  

How it's done: The mixture is placed within distensible scars and provides correction for more than 1 year.
Cosmetic condition & treatment area: Acne scars
Recovery: Up to five days
Complications: Adverse effects include a prolonged inflammatory reaction in select patients, which is probably related to an idiosyncratic sensitivity response to the products. It has been used extensively in patients who are allergic to Zyderm
Lasting: 6 months to 2 years.
Cost: From $300 to $500, procedure will vary greatly with how much is used.


Description: New generation of injection fillers containing hyaluronic acid. It is prepared from bio fermentative hyaluronic acid by patented process. It is a monocomponent formulation – containing only one substance. It is suitable for fillings of larger areas and for wrinkle removal.

How it's done: Esthelis can be used with allergy skin test. It takes approximately 30 minutes to perform. The final result is visible in 1 to 2 days.
Cosmetic condition & treatment area: Wrinkles, augmentation of the lips, cheeks or chin
Recovery: Few days.
Complications: Low risk of allergies and side effects. It tends to result in less swelling than Restylane products.
Lasting: Up to 9 months.
Cost: 1ml $450

Collagen Injections

Description: The collagen used comes from highly purified bovine collagen.  

How it's done: A skin test is usually performed several weeks before receiving any collagen injection. Receiving Collagen injections can take anywhere from a few minutes to half an hour.
Cosmetic condition & treatment area: Collagen can be used to either smooth wrinkles, sculpt lips or fill in scars.
Recovery: One or two days.
Complications: Potential side effects to the treatment are: Infection, Skin Peeling, Scarring and Lumpiness.
Lasting: Up to six months.
Cost: Around $350 to $450.


Description: Sculptra is a novel injectable filler that is composed of poly-L-lactic acid. This material has been used for years to make suture materials and is known to be highly biocompatible. It has been approved for treatment of HIV facial lipoatrophy.

How it's done: It is injected in small amounts using a very fine needle. Your health care provider may apply a topical or local anesthetic. 
Cosmetic condition & treatment area: It is intended for restoration and /or correction of the signs of facial fat loss. Scuptra is injected below the surface of the skin in the area of fat loss. Sculptra provides an increase in skin thickness. It will not correct the underlying cause of the facial fat loss, but will help improve the appearance by increasing skin thickness in the treated area.
Recovery: 3 to 17 days
Complications: The most common side effects include injection-related side effects at the site of the injections, such as bleeding, tenderness or pain, redness, bruising, or swelling.
Lasting: Results can last up to 2 years, multiple treatments over several weeks are required for the best results; however, results can last up to 2 years.
Cost: Sculptra costs $200 per cc.


Description: Liposuction has made the harvesting of fat a simpler procedure, and for grafting, this is performed with a syringe in an atraumatic manner. The best donor sites include the thighs, buttocks, knees, and abdomen.

How it's done: The fat is withdrawn from certain donor areas, either using a needle, or through techniques similar to those used during liposuction. The fat is then treated through a centrifuge and injected back into the needed areas. These areas are overfilled with fat to allow for absorption following treatment. This may make the face appear puffy or swollen, temporarily.
Cosmetic condition & treatment area: For large, atrophic defects that include skin and fat.
Recovery: Swelling and puffiness may only a few weeks.
Complications: Bruising, swelling or redness in both the donor and injected areas are expected.
Lasting: Three to six months.
Cost: Around $1000, to maintain the results, multiple treatments are expected.

Hylaform (hylan B gel)

Description: Hylaform B gel (previously known as hylan B gel) is a hyaluronic acid derivative of an avian polysaccharide from the rooster comb. It is a cross-linked derivative of natural hyaluronan polymer with little immunologic activity and no species specificity.

How it's done: It is an intradermal injection used to augment scars. The procedure requires a series of injections rather than a single treatment session.
Cosmetic condition & treatment area: Used to augment scars and for smoothing unwanted lines and wrinkles.
Recovery: No recovery time.
Complications:  The side effects of Hylaform may include: Bruising, Redness, Swelling, Pain, Tenderness and Nodules.
Lasting: Hylaform last approximately twelve weeks.
Cost: The average cost of a single treatment is usually $400-$800.


Description: Formerly known as Radience, Radiesse is a synthetic injectable filler that non-surgically reduces most wrinkles, creases and scars by augmenting your body’s natural collagen supply. Composed of microspheres in a biocompatible gel, Radiesse is made from the same minerals found in our bones.

How it's done: Treatments typically take 30 minutes and require local anesthetic. Calcium hydroxyapatite does not elicit an inflammatory reaction, so no allergy testing is necessary.
Cosmetic condition & treatment area: laugh lines, peri-oral lines, depressed scars and oral commissures (downturned corners of the mouth).
Recovery: Few days.
Complications: Side effects such as swelling or bruising
Lasting: May last 6-24 months.
Cost: From $650 to $800 per syringe.

Injectibles FAQs
 How long do injectables last?
Longevity of BOTOX® Cosmetic and Facial Fillers can vary from person to person. However, in general, BOTOX® Cosmetic lasts 3 to 5 months, Restylane and JUVEDERM® Injectable Gel last 6 to 8 months in facial folds, JUVEDERM® Injectable Gel lasts 3 to 5 months in the lips, Radiesse lasts 9 to 12 months in the folds, and Artefill lasts 1 to 5 years.

 Is BOTOX® Cosmetic safe?
t is consider relatively safe, but Health Canada Issues New Warnings For Botox Users, to find out more, click here.

 Do injectables hurt?
Any injection will cause mild pain.

 Will I bruise?
This varies from person to person. Facial fillers, especially near the corners of the mouth, often result in mild bruising.

What Is Off-Label Use of Cosmetic Injectables?
The use of the cosmetic injectables other than the FDA approved use.

Do injectables accomplish the same thing as a facelift?
No. Injectables are often complementary to facelifts. Surgery often softens but does not eliminate deep nasolabial folds and marionette lines. In these cases, direct injectable fillers such as Restylane, Radiesse, JUVEDERM® Injectable Gel, or Artefill can complement surgical treatment.

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